Ontology highlight
ABSTRACT:
SUBMITTER: Raud B
PROVIDER: S-EPMC6747686 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Raud Brenda B Roy Dominic G DG Divakaruni Ajit S AS Tarasenko Tatyana N TN Franke Raimo R Ma Eric H EH Samborska Bozena B Hsieh Wei Yuan WY Wong Alison H AH Stüve Philipp P Arnold-Schrauf Catharina C Guderian Melanie M Lochner Matthias M Rampertaap Shakuntala S Romito Kimberly K Monsale Joseph J Brönstrup Mark M Bensinger Steven J SJ Murphy Anne N AN McGuire Peter J PJ Jones Russell G RG Sparwasser Tim T Berod Luciana L
Cell metabolism 20180628 3
T cell subsets including effector (T<sub>eff</sub>), regulatory (T<sub>reg</sub>), and memory (T<sub>mem</sub>) cells are characterized by distinct metabolic profiles that influence their differentiation and function. Previous research suggests that engagement of long-chain fatty acid oxidation (LC-FAO) supports Foxp3<sup>+</sup> T<sub>reg</sub> cell and T<sub>mem</sub> cell survival. However, evidence for this is mostly based on inhibition of Cpt1a, the rate-limiting enzyme for LC-FAO, with the ...[more]