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The Molecular Function of ? Receptors: Past, Present, and Future.

ABSTRACT: The ?1 and ?2 receptors are enigmatic proteins that have attracted attention for decades due to the chemical diversity and therapeutic potential of their ligands. However, despite ongoing clinical trials with ? receptor ligands for multiple conditions, relatively little is known regarding the molecular function of these receptors. In this review, we revisit past research on ? receptors and discuss the interpretation of these data in light of recent developments. We provide a synthesis of emerging structural and genetic data on the ?1 receptor and discuss the recent cloning of the ?2 receptor. Finally, we discuss the major questions that remain in the study of ? receptors.

SUBMITTER: Schmidt HR 

PROVIDER: S-EPMC6748033 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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The Molecular Function of σ Receptors: Past, Present, and Future.

Schmidt Hayden R HR   Kruse Andrew C AC  

Trends in pharmacological sciences 20190803 9

The σ<sub>1</sub> and σ<sub>2</sub> receptors are enigmatic proteins that have attracted attention for decades due to the chemical diversity and therapeutic potential of their ligands. However, despite ongoing clinical trials with σ receptor ligands for multiple conditions, relatively little is known regarding the molecular function of these receptors. In this review, we revisit past research on σ receptors and discuss the interpretation of these data in light of recent developments. We provide  ...[more]

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