Ontology highlight
ABSTRACT:
SUBMITTER: Narayanan A
PROVIDER: S-EPMC6748080 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Narayanan Ashwin A Gagliardi Filippo F Gallotti Alberto L AL Mazzoleni Stefania S Cominelli Manuela M Fagnocchi Luca L Pala Mauro M Piras Ignazio S IS Zordan Paola P Moretta Nicole N Tratta Elisa E Brugnara Gianluca G Altabella Luisa L Bozzuto Giuseppina G Gorombei Petra P Molinari Agnese A Padua Rose-Ann RA Bulfone Alessandro A Politi Letterio S LS Falini Andrea A Castellano Antonella A Mortini Pietro P Zippo Alessio A Poliani Pietro L PL Galli Rossella R
Cell death and differentiation 20181211 9
Achaete-scute homolog 1 gene (ASCL1) is a gene classifier for the proneural (PN) transcriptional subgroup of glioblastoma (GBM) that has a relevant role in the neuronal-like differentiation of GBM cancer stem cells (CSCs) through the activation of a PN gene signature. Besides prototypical ASCL1 PN target genes, the molecular effectors mediating ASCL1 function in regulating GBM differentiation and, most relevantly, subgroup specification are currently unknown. Here we report that ASCL1 not only p ...[more]