Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health.

ABSTRACT: Intelligence and education are predictive of better physical and mental health, socioeconomic position (SEP), and longevity. However, these associations are insufficient to prove that intelligence and/or education cause these outcomes. Intelligence and education are phenotypically and genetically correlated, which makes it difficult to elucidate causal relationships. We used univariate and multivariable Mendelian randomization to estimate the total and direct effects of intelligence and educational attainment on mental and physical health, measures of socioeconomic position, and longevity. Both intelligence and education had beneficial total effects. Higher intelligence had positive direct effects on income and alcohol consumption, and negative direct effects on moderate and vigorous physi

SUBMITTER: Davies NM 

PROVIDER: S-EPMC6748790 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature