Ontology highlight
ABSTRACT:
SUBMITTER: Pahor M
PROVIDER: S-EPMC6748815 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Pahor Marco M Anton Stephen D SD Beavers Daniel P DP Cauley Jane A JA Fielding Roger A RA Kritchevsky Stephen B SB Leeuwenburgh Christiaan C Lewis Kristina H KH Liu Christine K CK Lovato Laura C LC Lu Jane J Manini Todd M TM McDermott Mary M MM Miller Michael E ME Newman Anne B AB Radziszewska Barbara B Stowe Cynthia L CL Tracy Russell P RP Walkup Michael P MP Wu Samuel S SS Ambrosius Walter T WT
The journals of gerontology. Series A, Biological sciences and medical sciences 20190901 10
<h4>Background</h4>Low-grade chronic inflammation, characterized by elevations in plasma Interleukin-6 (IL-6), is an independent risk factor of impaired mobility in older persons. Angiotensin receptor blockers and omega-3 polyunsaturated fatty acids (ω-3) may reduce IL-6 and may potentially improve physical function. To assess the main effects of the angiotensin receptor blocker losartan and ω-3 as fish oil on IL-6 and 400 m walking speed, we conducted the ENRGISE Pilot multicenter randomized cl ...[more]