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A 7-Hydroxybenzoxazinone-Containing Fluorescence Turn-On Probe for Biothiols and Its Bioimaging Applications.


ABSTRACT: In this work, a novel 7-hydroxybenzoxazinone-based fluorescent probe (PBD) for the selective sensing of biothiols is reported. Upon treatment with biothiols, PBD shows a strong fluorescence enhancement (up to 70-fold) and a large Stokes shift (155 nm). Meanwhile, this probe exhibits high resistance to interference from other amino acids and competing species. PBD features good linearity ranges with a low detection limit of 14.5 nM for glutathione (GSH), 17.5 nM for cysteine (Cys), and 80.0 nM for homocysteine (Hcy), respectively. Finally, the potential utility of this probe for biothiol sensing in living HeLa cells is demonstrated.

SUBMITTER: Li B 

PROVIDER: S-EPMC6749190 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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A 7-Hydroxybenzoxazinone-Containing Fluorescence Turn-On Probe for Biothiols and Its Bioimaging Applications.

Li Bin B   Zhang Datong D   An Ruibing R   Zhu Yaling Y  

Molecules (Basel, Switzerland) 20190827 17


In this work, a novel 7-hydroxybenzoxazinone-based fluorescent probe (<b>PBD</b>) for the selective sensing of biothiols is reported. Upon treatment with biothiols, <b>PBD</b> shows a strong fluorescence enhancement (up to 70-fold) and a large Stokes shift (155 nm). Meanwhile, this probe exhibits high resistance to interference from other amino acids and competing species. <b>PBD</b> features good linearity ranges with a low detection limit of 14.5 nM for glutathione (GSH), 17.5 nM for cysteine  ...[more]

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