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Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum.

ABSTRACT: Sixteen new prenylated flavonoids, sinoflavonoids P-Z (1-11) and sinoflavonoids NA-NE (12-16), were isolated from the fruit of Sinopodophyllum hexandrum, along with eight known analogues (17-24). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, 1H-NMR, 13C-NMR, HSQC, HMBC). The cytotoxic activities of compounds 1-18, 20, and 22 were evaluated by MTT assay. Compound 6 showed the most potent cytotoxicity in MCF-7, and HepG2 cell lines, with IC50 values of 6.25 and 3.83 ?M, respectively.

SUBMITTER: Sun Y

PROVIDER: S-EPMC6749350 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum.

Sun Yanjun Y Chen Haojie H Wang Junmin J Gao Meiling M Zhao Chen C Han Ruijie R Chen Hui H Li Meng M Xue Guimin G Feng Weisheng W

Molecules (Basel, Switzerland) 20190903 17

Sixteen new prenylated flavonoids, sinoflavonoids P-Z (1-11) and sinoflavonoids NA-NE (12-16), were isolated from the fruit of Sinopodophyllum hexandrum, along with eight known analogues (17-24). Their structures were elucidated on the basis of extensive spectroscopic data (HR-ESI-MS, 1H-NMR, 13C-NMR, HSQC, HMBC). The cytotoxic activities of compounds 1-18, 20, and 22 were evaluated by MTT assay. C ...[more]

PMID: 31484370

Dataset Information

Sixteen New Prenylated Flavonoids from the Fruit of Sinopodophyllum hexandrum.

Publications

Sixteen New Prenylated Flavonoids from the Fruit of <i>Sinopodophyllum hexandrum</i>.

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