Ontology highlight
ABSTRACT:
SUBMITTER: Fan ZF
PROVIDER: S-EPMC6749477 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190901 17
Based on the structural scaffolds of natural products, two series of flavonoid derivatives, for a total of twelve compounds, were designed and synthesized as potential human telomerase inhibitors. Using a modified TRAP-PCR assay, compound <b>5c</b> exhibited the most potent inhibitory activity against human telomerase with an IC<sub>50</sub> value of less than 50 μM. In vitro, the results demonstrated that compound <b>5c</b> had potent anticancer activity against five classes of tumor cell lines ...[more]