Ontology highlight
ABSTRACT:
SUBMITTER: Papoutsopoulou S
PROVIDER: S-EPMC6749845 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Papoutsopoulou Stamatia S Burkitt Michael D MD Bergey François F England Hazel H Hough Rachael R Schmidt Lorraine L Spiller David G DG White Michael H R MHR Paszek Pawel P Jackson Dean A DA Martins Dos Santos Vitor A P VAP Sellge Gernot G Pritchard D Mark DM Campbell Barry J BJ Müller Werner W Probert Chris S CS
Frontiers in immunology 20190911
The heterogeneous nature of inflammatory bowel disease (IBD) presents challenges, particularly when choosing therapy. Activation of the NF-κB transcription factor is a highly regulated, dynamic event in IBD pathogenesis. Using a lentivirus approach, NF-κB-regulated luciferase was expressed in patient macrophages, isolated from frozen peripheral blood mononuclear cell samples. Following activation, samples could be segregated into three clusters based on the NF-κB-regulated luciferase response. T ...[more]