Evaluating the IgMi mouse as a novel tool to study B-cell biology.
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ABSTRACT:
SUBMITTER: Sahputra R
PROVIDER: S-EPMC6750126 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Evaluating the IgMi mouse as a novel tool to study B-cell biology.
Sahputra Rinal R Yam-Puc Juan Carlos JC Waisman Ari A Muller Werner W Else Kathryn J KJ
European journal of immunology 20181026 12
The IgMi mouse fails to secrete antibodies or class switch its BCR from IgM. Our study reveals that other cellular compartments, including B-cell subsets, DC subsets, GC B cells and T<sub>FH</sub> cells are perturbed in the IgMi mouse, thus presenting important additional considerations when using the mouse to explore the role of secreted antibody. ...[more]
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