Ontology highlight
ABSTRACT:
SUBMITTER: Tuteja S
PROVIDER: S-EPMC6751004 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Tuteja Sony S Ferguson Jane F JF
Circulation. Genomic and precision medicine 20190828 9
The gut microbiome is emerging as an important contributor to both cardiovascular disease risk and metabolism of xenobiotics. Alterations in the intestinal microbiota are associated with atherosclerosis, dyslipidemia, hypertension, and heart failure. The microbiota have the ability to metabolize medications, which can results in altered drug pharmacokinetics and pharmacodynamics or formation of toxic metabolites which can interfere with drug response. Early evidence suggests that the gut microbi ...[more]