Influence of nonsynaptic ?1 glycine receptors on ethanol consumption and place preference.
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ABSTRACT:
SUBMITTER: Munoz B
PROVIDER: S-EPMC6751026 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Influence of nonsynaptic α1 glycine receptors on ethanol consumption and place preference.
Muñoz Braulio B Gallegos Scarlet S Peters Christian C Murath Pablo P Lovinger David M DM Homanics Gregg E GE Aguayo Luis G LG
Addiction biology 20190318 2
Here, we used knock-in (KI) mice that have ethanol-insensitive alpha 1 glycine receptors (GlyRs) (KK385/386AA) to examine how alpha 1 GlyRs might affect binge drinking and conditioned place preference. Data show that tonic alpha 1 GlyR-mediated currents were exclusively sensitive to ethanol only in wild-type mice. Behavioral studies showed that the KI mice have a higher intake of ethanol upon first exposure to drinking and greater conditioned place preference to ethanol. This study suggests that ...[more]
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