Ontology highlight
ABSTRACT:
SUBMITTER: Claser C
PROVIDER: S-EPMC6751193 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Claser Carla C Nguee Samantha Yee Teng SYT Balachander Akhila A Wu Howland Shanshan S Becht Etienne E Gunasegaran Bavani B Hartimath Siddesh V SV Lee Audrey W Q AWQ Theng Theng Ho Jacqueline J Bing Ong Chee C Newell Evan W EW Goggi Julian J Guan Ng Lai L Renia Laurent L
Nature communications 20190918 1
Malaria-associated acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are life-threatening manifestations of severe malaria infections. The pathogenic mechanisms that lead to respiratory complications, such as vascular leakage, remain unclear. Here, we confirm that depleting CD8<sup>+</sup>T cells with anti-CD8β antibodies in C57BL/6 mice infected with P. berghei ANKA (PbA) prevent pulmonary vascular leakage. When we transfer activated parasite-specific CD8<sup>+</sup>T cells ...[more]