Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC6751195 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Liu Gang G Zhang Qianwen Q Xia Li L Shi Mengjuan M Cai Jin J Zhang Haowei H Li Jia J Lin Guanglan G Xie Weidong W Zhang Yaou Y Xu Naihan N
Cell death & disease 20190918 10
CELF6, a member of the CELF family of RNA-binding proteins, regulates muscle-specific alternative splicing and contributes to the pathogenesis of myotonic dystrophy (DM), however the role of CELF6 in cancer cell proliferation is less appreciated. Here, we show that the expression of CELF6 is cell cycle regulated. The cell cycle-dependent expression of CELF6 is mediated through the ubiquitin-proteasome pathway, SCF-β-TrCP recognizes a nonphospho motif in CELF6 and regulates its proteasomal degrad ...[more]