Dataset Information

Large-scale narrative events in popular cinema.

ABSTRACT: Most experiments in event perception and cognition have focused on events that are only a few minutes in length, and the previous research on popular movies is consistent with this temporal scope. Scenes are generally between a few seconds and a few minutes in duration. But popular movies also offer an opportunity to explore larger events-variously called acts, major parts, or large-scale parts by film theorists-in which the boundaries often have few if any unique physical attributes. These units tend to be between about 20 to 35?min in duration. The present study had observers watch seven movies they had not seen before and, over the course of several days and with ample justifications, reflect on them, and then segment them into two to six parts with the aid of a running description of the narrative. Results showed consistency across viewers' segmentations, consistency with film-theoretic segmentations, and superiority over internet subjects who had access to only the scenarios used by the movie viewers. Thus, these results suggest that there are large scale events in movies; they support a view that their events are organized meronomically, layered with units of different sizes and with boundaries shared across layers; and they suggest that these larger-scale events can be discerned through cognitive, not perceptual, means.

SUBMITTER: Cutting JE

PROVIDER: S-EPMC6751234 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Large-scale narrative events in popular cinema.

Cutting James E JE Armstrong Kacie L KL

Cognitive research: principles and implications 20190918 1

Most experiments in event perception and cognition have focused on events that are only a few minutes in length, and the previous research on popular movies is consistent with this temporal scope. Scenes are generally between a few seconds and a few minutes in duration. But popular movies also offer an opportunity to explore larger events-variously called acts, major parts, or large-scale parts by film theorists-in which the boundaries often have few if any unique physical attributes. These unit ...[more]

PMID: 31535277

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Project description:Background: The musculoskeletal toxicity of immune checkpoint inhibitors (ICIs) is receiving increasing attention with clinical experience. Nevertheless, the absence of a systematic investigation into the musculoskeletal toxicity profile of ICIs currently results in the under-recognition of associated adverse events. Further and more comprehensive investigations are warranted to delineate the musculoskeletal toxicity profile of ICIs and characterize these adverse events. Material and methods: The present study employed the FDA Adverse Event Reporting System database to collect adverse events between January 2010 and March 2021. We utilized both the reporting odds ratio and the Bayesian confidence propagation neural network algorithms to identify suspected musculoskeletal adverse events induced by ICIs. Subsequently, the clinical characteristics and comorbidities of the major musculoskeletal adverse events were analyzed. The risk of causing these events with combination therapy versus monotherapy was compared using logistic regression model and Ω shrinkage measure model. Results: The musculoskeletal toxicity induced by ICIs primarily involves muscle tissue, including neuromuscular junctions, fascia, tendons, and tendon sheaths, as well as joints, spine, and bones, including cartilage. The toxicity profile of PD-1/PD-L1 and CTLA-4 inhibitors varies, wherein the PD-1 inhibitor pembrolizumab exhibits a heightened overall risk of inducing musculoskeletal adverse events. The major ICIs-induce musculoskeletal adverse events, encompassing conditions such as myositis, neuromyopathy (including myasthenia gravis, Lambert-Eaton myasthenic syndrome, Guillain-Barré syndrome, and Chronic inflammatory demyelinating polyradiculoneuropathy), arthritis, fractures, myelitis, spinal stenosis, Sjogren's syndrome, fasciitis, tenosynovitis, rhabdomyolysis, rheumatoid myalgia, and chondrocalcinosis. Our study provides clinical characteristics and comorbidities of the major ICIs-induced musculoskeletal adverse events. Furthermore, the combination therapy of nivolumab and ipilimumab does not result in a statistically significant escalation of the risk associated with the major musculoskeletal adverse events. Conclusion: Immune checkpoint inhibitors administration triggers a range of musculoskeletal adverse events, warranting the optimization of their management during clinical practice.

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Large-scale narrative events in popular cinema.

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Large-scale narrative events in popular cinema.

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