Specific Glioma Prognostic Subtype Distinctions Based on DNA Methylation Patterns.
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ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC6751377 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Specific Glioma Prognostic Subtype Distinctions Based on DNA Methylation Patterns.
Chen Xueran X Zhao Chenggang C Zhao Zhiyang Z Wang Hongzhi H Fang Zhiyou Z
Frontiers in genetics 20190912
DNA methylation is an important regulator of gene expression and may provide an important basis for effective glioma diagnosis and therapy. Here, we explored specific prognosis subtypes based on DNA methylation status using 653 gliomas from The Cancer Genome Atlas (TCGA) database. Five subgroups were distinguished by consensus clustering using 11,637 cytosines preceding a guanosine (CpGs) that significantly influenced survival. The specific DNA methylation patterns were correlated with age, tumo ...[more]
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