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Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes.

ABSTRACT: A novel formic acid-assisted rapid and efficient route for C-S bond construction via the thiol-ene reaction has been reported. Exclusively, the anti-Markovnikov product was obtained in good to excellent yield using the developed protocol. Various styrenes and thiols bearing different functionalities were well tolerated. The reaction also provided a good yield of sulfones in a one-pot two-step protocol. The developed method is operationally simple, green, metal-free, solvent-free, and having a high atom economy with high regioselectivity.

SUBMITTER: Upadhyay R

PROVIDER: S-EPMC6751736 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Formic Acid-Driven Rapid and Green Anti-Markovnikov Hydrothiolation of Styrenes.

Upadhyay Rahul R Rana Rohit R Sood Aakriti A Maurya Sushil K SK

ACS omega 20190904 12

A novel formic acid-assisted rapid and efficient route for C-S bond construction via the thiol-ene reaction has been reported. Exclusively, the anti-Markovnikov product was obtained in good to excellent yield using the developed protocol. Various styrenes and thiols bearing different functionalities were well tolerated. The reaction also provided a good yield of sulfones in a one-pot two-step protocol. The developed method is operationally simple, green, metal-free, solvent-free, and having a hi ...[more]

PMID: 31552354

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