Ontology highlight
ABSTRACT:
SUBMITTER: Zhou L
PROVIDER: S-EPMC6752716 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Zhou Liran L Husted Hongmei H Moore Todd T Lu Mason M Deng Defeng D Liu Yan Y Ramachandran Vijaya V Arumugam Thiruvengadam T Niehrs Christof C Wang Huamin H Chiao Paul P Ling Jianhua J Curran Michael A MA Maitra Anirban A Hung Mien-Chie MC Lee Jeffrey E JE Logsdon Craig D CD Hwang Rosa F RF
Science translational medicine 20181001 464
Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and it is unclear whether its stromal infiltrate contributes to its aggressiveness. Here, we demonstrate that Dickkopf-3 (DKK3) is produced by pancreatic stellate cells and is present in most human PDAC. DKK3 stimulates PDAC growth, metastasis, and resistance to chemotherapy with both paracrine and autocrine mechanisms through NF-κB activation. Genetic ablation of DKK3 in an autochthonous model of PDAC inhibited tumor growth, induce ...[more]