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Cyclic Cell-Penetrating Peptides with Single Hydrophobic Groups.

ABSTRACT: A new family of cyclic cell-penetrating peptides (CPPs) has been discovered; they differ from previously reported cyclic CPPs by containing only a single hydrophobic residue. The optimal CPP structure consists of four arginine residues and a hydrophobic residue with a long alkyl chain (e.g., a decyl group) in a cyclohexapeptide ring. The most active member of this family, CPP 17, has an intrinsic cellular entry efficiency similar to that of cyclic CPP12, the most active CPP reported to date. However, CPP 17 is 2.8 times more active than CPP12 under high serum protein concentrations, presumably because of the lower protein binding. CPP 17 enters the cell primarily by direct translocation at a relatively low concentration (?5??m).

SUBMITTER: Song J

PROVIDER: S-EPMC6752721 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Cyclic Cell-Penetrating Peptides with Single Hydrophobic Groups.

Song Jian J Qian Ziqing Z Sahni Ashweta A Chen Kuangyu K Pei Dehua D

Chembiochem : a European journal of chemical biology 20190724 16

A new family of cyclic cell-penetrating peptides (CPPs) has been discovered; they differ from previously reported cyclic CPPs by containing only a single hydrophobic residue. The optimal CPP structure consists of four arginine residues and a hydrophobic residue with a long alkyl chain (e.g., a decyl group) in a cyclohexapeptide ring. The most active member of this family, CPP 17, has an intrinsic cellular entry efficiency similar to that of cyclic CPP12, the most active CPP reported to date. How ...[more]

PMID: 31298779

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