Ontology highlight
ABSTRACT:
SUBMITTER: Kaur R
PROVIDER: S-EPMC6752747 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Kaur Ramanpreet R Cavanagh Katie L KL Rodríguez-Hornedo Naír N Matzger Adam J AJ
Crystal growth & design 20170908 10
A drug-drug cocrystal of two anticonvulsants, lamotrigine and phenobarbital, is presented. In the crystal structure, molecules form heterodimers via N-H···O and N-H···N hydrogen bonding. The intrinsic dissolution rate (IDR) and solubility of the cocrystal were measured in phosphate buffer (pH 7.2) and simulated gastric fluid (without pepsin), and compared to pure APIs. Dissolution experiments found suppressed IDR of the cocrystal with rates in the order pure PB > pure LTG > cocrystal. The solubi ...[more]