White matter microstructure relates to lassitude but not diagnosis in adolescents with depression.

ABSTRACT: The neurobiology of adolescent depression remains poorly understood. Initial studies suggested impaired white matter microstructure in adults and adolescents, but findings have not been consistent. Challenges in this literature have included small samples, medication confounds and inconsistent correction for type I error. This study addressed these issues in a new examination of fractional anisotropy (FA) in adolescents with major depressive disorder (MDD) using diffusion tensor imaging. We examined FA in 81 adolescents aged 12-19 (44 MDD [all unmedicated], 37 controls). We conducted logistic regression analyses to examine the odds of MDD versus control based on FA within standard white matter tracts that were delineated by probabilistic tractography. We also examined relationships between

SUBMITTER: Cullen KR 

PROVIDER: S-EPMC6752996 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature