Functional organization of motor networks in the lumbosacral spinal cord of non-human primates.

ABSTRACT: Implantable spinal-cord-neuroprostheses aiming to restore standing and walking after paralysis have been extensively studied in animal models (mainly cats) and have shown promising outcomes. This study aimed to take a critical step along the clinical translation path of these neuroprostheses, and investigated the organization of the neural networks targeted by these implants in a non-human primate. This was accomplished by advancing a microelectrode into various locations of the lumbar enlargement of the spinal cord, targeting the ventral horn of the gray matter. Microstimulation in these locations produced a variety of functional movements in the hindlimb. The resulting functional map of the spinal cord in monkeys was found to have a similar overall organization along the length of the sp

SUBMITTER: Toossi A 

PROVIDER: S-EPMC6753145 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature