Ontology highlight
ABSTRACT:
SUBMITTER: Hwang SY
PROVIDER: S-EPMC6753481 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Hwang Soon Young SY Kang Mi Ae MA Baik Chul Joon CJ Lee Yejin Y Hang Ngo Thanh NT Kim Byung-Gyu BG Han Joo Seok JS Jeong Jae-Hoon JH Park Daechan D Myung Kyungjae K Lee Jong-Soo JS
Nucleic acids research 20190901 17
The pleiotropic CCCTC-binding factor (CTCF) plays a role in homologous recombination (HR) repair of DNA double-strand breaks (DSBs). However, the precise mechanistic role of CTCF in HR remains largely unclear. Here, we show that CTCF engages in DNA end resection, which is the initial, crucial step in HR, through its interactions with MRE11 and CtIP. Depletion of CTCF profoundly impairs HR and attenuates CtIP recruitment at DSBs. CTCF physically interacts with MRE11 and CtIP and promotes CtIP rec ...[more]