Ontology highlight
ABSTRACT:
SUBMITTER: Chahal KK
PROVIDER: S-EPMC6754133 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Chahal Kirti Kandhwal KK Li Jie J Kufareva Irina I Parle Milind M Durden Donald L DL Wechsler-Reya Robert J RJ Chen Clark C CC Abagyan Ruben R
PloS one 20190920 9
Dysregulation of the seven-transmembrane (7TM) receptor Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway contributes to the development of cancers including basal cell carcinoma (BCC) and medulloblastoma (MB). However, SMO-specific antagonists produced mixed results in clinical trials, marked by limited efficacy and high rate of acquired resistance in tumors. Here we discovered that Nilotinib, an approved inhibitor of several kinases, possesses an anti-Hh activity, at ...[more]