Ontology highlight
ABSTRACT:
SUBMITTER: Gruber JJ
PROVIDER: S-EPMC6754178 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Gruber Joshua J JJ Chen Justin J Geller Benjamin B Jäger Natalie N Lipchik Andrew M AM Wang Guangwen G Kurian Allison W AW Ford James M JM Snyder Michael P MP
Cell reports 20190801 8
Individuals with a single functional copy of the BRCA2 tumor suppressor have elevated risks for breast, ovarian, and other solid tumor malignancies. The exact mechanisms of carcinogenesis due to BRCA2 haploinsufficiency remain unclear, but one possibility is that at-risk cells are subject to acute periods of decreased BRCA2 availability and function ("BRCA2-crisis"), which may contribute to disease. Here, we establish an in vitro model for BRCA2-crisis that demonstrates chromatin remodeling and ...[more]