Ontology highlight
ABSTRACT:
SUBMITTER: Njomen E
PROVIDER: S-EPMC6754308 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Cell chemical biology 20190718 9
The proteolytic arm of the protein homeostasis network is maintained by both the ubiquitin-proteasome system (UPS) and autophagy. A well-balanced crosstalk between the two catabolic pathways ensures energy-efficient maintenance of cellular function. Our current understanding of the crosstalk between the UPS and autophagy is centered around substrate ubiquitination. Herein we report an additional method of crosstalk involving ubiquitin-independent 20S proteasome regulation of autophagosome-lysoso ...[more]