Ontology highlight
ABSTRACT:
SUBMITTER: Bick AG
PROVIDER: S-EPMC6754626 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Bick Alexander G AG Akwo Elvis E Robinson-Cohen Cassianne C Lee Kyung K Lynch Julie J Assimes Themistocles L TL DuVall Scott S Edwards Todd T Fang Huaying H Freiberg S Matthew SM Giri Ayush A Huffman Jennifer E JE Huang Jie J Hull Leland L Kember Rachel L RL Klarin Derek D Lee Jennifer S JS Levin Michael M Miller Donald R DR Natarajan Pradeep P Saleheen Danish D Shao Qing Q Sun Yan V YV Tang Hua H Wilson Otis O Chang Kyong-Mi KM Cho Kelly K Concato John J Gaziano J Michael JM Kathiresan Sekar S O'Donnell Christopher J CJ Rader Daniel J DJ Tsao Philip S PS Wilson Peter W PW Hung Adriana M AM Damrauer Scott M SM
Circulation 20190724 12
<h4>Background</h4>Approximately 13% of black individuals carry 2 copies of the apolipoprotein L1 (<i>APOL1</i>) risk alleles G1 or G2, which are associated with 1.5- to 2.5-fold increased risk of chronic kidney disease. There have been conflicting reports as to whether an association exists between <i>APOL1</i> risk alleles and cardiovascular disease (CVD) that is independent of the effects of <i>APOL1</i> on kidney disease. We sought to test the association of <i>APOL1</i> G1/G2 alleles with c ...[more]