Ontology highlight
ABSTRACT:
SUBMITTER: Zhu W
PROVIDER: S-EPMC6754764 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Zhu Wende W Botticelli Erin M EM Kery Rachel E RE Mao Yanfei Y Wang Xin X Yang Anli A Wang Xianling X Zhou Jie J Zhang Xun X Soberman Roy J RJ Klibanski Anne A Zhou Yunli Y
Developmental biology 20190710 1
The imprinted delta like 1 homolog (DLK1) - thyroxine deiodinase type III (DIO3) locus regulates development and growth. Its imprinting regulation involves two differentially methylated regions (DMRs), intergenic-DMR (IG-DMR) and maternally expressed gene 3-DMR (Meg3-DMR). In mice, a maternal deletion of the IG-DMR leads to LOI in the locus, proving that the IG-DMR is a cis-acting imprinting control region of the locus. However, the Meg3-DMR overlaps with the promoter, exon 1 and intron 1 of the ...[more]