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Association of HLA locus alleles with posttraumatic stress disorder.


ABSTRACT: BACKGROUND:Immune dysregulation has been widely observed in those with posttraumatic stress disorder (PTSD). An individual's immune response is shaped, in part, by the highly polymorphic Human Leukocyte Antigen (HLA) locus that is associated with major psychiatric disorders such as schizophrenia, major depression and bipolar disorder. The aim of the current study was to investigate the association between common HLA alleles and PTSD. METHODS:Genome-wide association data was used to predict alleles of 7 classical polymorphic HLA genes (A, B, C, DRB1, DQA1, DQB1, DPB1) in 403 lifetime PTSD cases and 369 trauma exposed controls of African ancestry. Association of HLA allelic variations with lifetime PTSD was analyzed using logistic regression, controlling for ancestry, sex and multiple comparisons. The effect of HLA alleles on gene expression was assessed by weighted correlation network analysis (WGCNA), using 353 subjects with available expression data. Enrichment analysis was performed using anRichment to identify associated pathways of each module. RESULTS:HLA-B*58:01 (p?=?0.035), HLA-C*07:01 (p?=?0.035), HLA-DQA1*01:01 (p?=?0.003), HLA-DQB1*05:01 (p?=?0.009) and HLA-DPB1*17:01 (p?=?0.017) were more common in PTSD cases, while HLA-A*02:01 (p?=?0.026), HLA-DQA1*05:05 (p?=?0.011) and HLA-DRB1*11:01 (p?

SUBMITTER: Katrinli S 

PROVIDER: S-EPMC6754776 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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<h4>Background</h4>Immune dysregulation has been widely observed in those with posttraumatic stress disorder (PTSD). An individual's immune response is shaped, in part, by the highly polymorphic Human Leukocyte Antigen (HLA) locus that is associated with major psychiatric disorders such as schizophrenia, major depression and bipolar disorder. The aim of the current study was to investigate the association between common HLA alleles and PTSD.<h4>Methods</h4>Genome-wide association data was used t  ...[more]

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