Ontology highlight
ABSTRACT:
SUBMITTER: You D
PROVIDER: S-EPMC6754812 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
You Dahea D Shin Hye Min HM Mosaad Fatimah F Richardson Jason R JR Aleksunes Lauren M LM
Journal of biochemical and molecular toxicology 20190321 6
Multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP) protect the brain by restricting the passage of chemicals across the blood-brain barrier. Prior studies have demonstrated the epigenetic regulation of MDR1 and BCRP in cancer cells treated with histone deacetylase (HDAC) inhibitors that enhance histone acetylation and gene transcription. In the present study, we tested the in vivo effects of two HDAC inhibitors, valproic acid (VPA; 400 mg/kg) and apicidin (5 mg/kg) ...[more]