Dataset Information

3-D Measurements of Acceleration-Induced Brain Deformation via Harmonic Phase Analysis and Finite-Element Models.

ABSTRACT: OBJECTIVE:To obtain dense spatiotemporal measurements of brain deformation from two distinct but complementary head motion experiments: linear and rotational accelerations. METHODS:This study introduces a strategy for integrating harmonic phase analysis of tagged magnetic resonance imaging (MRI) and finite-element models to extract mechanically representative deformation measurements. The method was calibrated using simulated as well as experimental data, demonstrated in a phantom including data with image artifacts, and used to measure brain deformation in human volunteers undergoing rotational and linear acceleration. RESULTS:Evaluation methods yielded a displacement error of 1.1 mm compared to human observers and strain errors between [Formula: see text] for linear acceleration and [Formula: see text] for rotational acceleration. This study also demonstrates an approach that can reduce error by 86% in the presence of corrupted data. Analysis of results shows consistency with 2-D motion estimation, agreement with external sensors, and the expected physical behavior of the brain. CONCLUSION:Mechanical regularization is useful for obtaining dense spatiotemporal measurements of in vivo brain deformation under different loading regimes. SIGNIFICANCE:The measurements suggest that the brain's 3-D response to mild accelerations includes distinct patterns observable using practical MRI resolutions. This type of measurement can provide validation data for computer models for the study of traumatic brain injury.

SUBMITTER: Gomez AD

PROVIDER: S-EPMC6754983 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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3-D Measurements of Acceleration-Induced Brain Deformation via Harmonic Phase Analysis and Finite-Element Models.

Gomez Arnold D AD Knutsen Andrew K AK Xing Fangxu F Lu Yuan-Chiao YC Chan Deva D Pham Dzung L DL Bayly Philip P Prince Jerry L JL

IEEE transactions on bio-medical engineering 20181008 5

<h4>Objective</h4>To obtain dense spatiotemporal measurements of brain deformation from two distinct but complementary head motion experiments: linear and rotational accelerations.<h4>Methods</h4>This study introduces a strategy for integrating harmonic phase analysis of tagged magnetic resonance imaging (MRI) and finite-element models to extract mechanically representative deformation measurements. The method was calibrated using simulated as well as experimental data, demonstrated in a phantom ...[more]

PMID: 30296208

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Project description:Diffuse axonal injury (DAI) is a severe form of traumatic brain injury and often induced by blunt trauma. The closed head impact acceleration (IA) model is the most widely used rodent DAI model. However, this model results in large variations of injury severity. Recently, the impact device/system was modified to improve the consistency of the impact energy, but variations of the head kinematics and subsequent brain injuries were still observed. This study was aimed to utilize a Finite Element (FE) model of a rat head/body and simulation to investigate the potential biomechanical factors influencing the impact energy transfer to the head. A detailed FE rat head model containing detailed skull and brain anatomy was developed based on the MRI, microCT and atlas data. The model consists of over 722,000 elements, of which 310,000 are in the brain. The white matter structures consisting of highly aligned axonal fibers were simulated with transversely isotropic material. The rat body was modeled to provide a realistic boundary at the spine-medulla junction. Rodent experiments including dynamic cortical deformation, brain-skull displacement, and IA kinematics were simulated to validate the FE model. The model was then applied to simulate the rat IA experiments. Parametric studies were conducted to investigate the effect of the helmet inclination angles (0°-5°) and skull stiffness (varied 20%) on the resulting head kinematics and maximum principal strain in the brain. The inclination angle of the helmet at 5° could vary head linear acceleration by 8-31%. The change in head rotational velocity was inversely related to the change in linear acceleration. Varying skull stiffness resulted in changes in head linear acceleration by 3% but with no effect on rotational velocity. The brain strain in the corpus callosum was only affected by head rotation while the strain in the brainstem was influenced by the combined head kinematics, local skull deformation, and head-neck position. Validated FE models of rat impact head injury can assist in exploring various biomechanical factors influencing the head impact response and internal brain response. Identification of these variables may help explain the variability of injury severity observed among experiments and across different labs.

Dataset Information

3-D Measurements of Acceleration-Induced Brain Deformation via Harmonic Phase Analysis and Finite-Element Models.

Publications

3-D Measurements of Acceleration-Induced Brain Deformation via Harmonic Phase Analysis and Finite-Element Models.

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