Reconstructing complex lineage trees from scRNA-seq data using MERLoT.
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ABSTRACT:
SUBMITTER: Parra RG
PROVIDER: S-EPMC6755101 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Reconstructing complex lineage trees from scRNA-seq data using MERLoT.
Parra R Gonzalo RG Papadopoulos Nikolaos N Ahumada-Arranz Laura L Kholtei Jakob El JE Mottelson Noah N Horokhovsky Yehor Y Treutlein Barbara B Soeding Johannes J
Nucleic acids research 20190901 17
Advances in single-cell transcriptomics techniques are revolutionizing studies of cellular differentiation and heterogeneity. It has become possible to track the trajectory of thousands of genes across the cellular lineage trees that represent the temporal emergence of cell types during dynamic processes. However, reconstruction of cellular lineage trees with more than a few cell fates has proved challenging. We present MERLoT (https://github.com/soedinglab/merlot), a flexible and user-friendly ...[more]
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