Implications for the migraine SNP rs1835740 in a Swedish cluster headache population.

ABSTRACT:

Background

Cluster headache is a severe headache disorder with unknown aetiology. The pathophysiology and symptoms present certain common features with migraine. Specifically, activation of the trigeminal vascular system seems to be involved in both disorders, which is hypothesized to result in neurogenic inflammation and vasodilation of the cerebral vessels. In addition, genetic factors have been implicated in both migraine and cluster headache.

Objective

In order to determine whether or not migraine and cluster headache share genetic risk factors, we screened two genetic variants known to increase the risk of migraine in Sweden in a Swedish cluster headache case-control study population.

Methods

In all, 541 patients and 581 control subjects were genotyped for rs1835

SUBMITTER: Ran C 

PROVIDER: S-EPMC6755538 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature