Ontology highlight
ABSTRACT:
SUBMITTER: Zheng P
PROVIDER: S-EPMC6755540 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zheng Peng P Li Yifan Y Wu Jing J Zhang Hanping H Huang Yu Y Tan Xunmin X Pan Junxi J Duan Jiajia J Liang Weiwei W Yin Bangmin B Deng Fengli F Perry Seth W SW Wong Ma-Li ML Licinio Julio J Wei Hong H Yu Gang G Xie Peng P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20190731 18
Myasthenia gravis (MG) is a devastating acquired autoimmune disease. Emerging evidence indicates that the gut microbiome plays a key role in maintaining immune system homeostasis. This work reports that MG is characterized by decreased α-phylogenetic diversity, and significantly disturbed gut microbiome and fecal metabolome. The altered gut microbial composition is associated with fecal metabolome changes, with 38.75% of altered bacterial operational taxonomic units showing significant correlati ...[more]