Ontology highlight
ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC6755801 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Lu Zhaojing Z Hu Xuebin X Reilly James J Jia Danna D Liu Fei F Yu Shanshan S Liu Xiliang X Xie Shanglun S Qu Zhen Z Qin Yayun Y Huang Yuwen Y Lv Yuexia Y Li Jingzhen J Gao Pan P Wong Fulton F Shu Xinhua X Tang Zhaohui Z Liu Mugen M
The Journal of biological chemistry 20190730 38
Mutations in human prominin 1 (<i>PROM1</i>), encoding a transmembrane glycoprotein localized mainly to plasma membrane protrusions, have been reported to cause retinitis pigmentosa, macular degeneration, and cone-rod dystrophy. Although the structural role of PROM1 in outer-segment (OS) morphogenesis has been demonstrated in <i>Prom1</i>-knockout mouse, the mechanisms underlying these complex disease phenotypes remain unclear. Here, we utilized a zebrafish model to further investigate PROM1's r ...[more]