Ontology highlight
ABSTRACT:
SUBMITTER: Jung SH
PROVIDER: S-EPMC6755978 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Jung Seung Hee SH Hwang Hyun Jung HJ Kang Donghee D Park Hyun A HA Lee Hyung Chul HC Jeong Daecheol D Lee Keunwook K Park Heon Joo HJ Ko Young-Gyu YG Lee Jae-Seon JS
Oncogene 20181018 10
Loss of PTEN, the major negative regulator of the PI3K/AKT pathway induces a cellular senescence as a failsafe mechanism to defend against tumorigenesis, which is called PTEN-loss-induced cellular senescence (PICS). Although many studies have indicated that the mTOR pathway plays a critical role in cellular senescence, the exact functions of mTORC1 and mTORC2 in PICS are not well understood. In this study, we show that mTOR acts as a critical relay molecule downstream of PI3K/AKT and upstream of ...[more]