Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers.
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ABSTRACT:
SUBMITTER: Louault K
PROVIDER: S-EPMC6756023 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Interactions between cancer-associated fibroblasts and tumor cells promote MCL-1 dependency in estrogen receptor-positive breast cancers.
Louault K K Bonneaud T L TL Séveno C C Gomez-Bougie P P Nguyen F F Gautier F F Bourgeois N N Loussouarn D D Kerdraon O O Barillé-Nion S S Jézéquel P P Campone M M Amiot M M Juin P P PP Souazé F F
Oncogene 20190110 17
Selective inhibition of BCL-2 is expected to enhance therapeutic vulnerability in luminal estrogen receptor-positive breast cancers. We show here that the BCL-2 dependency of luminal tumor cells is nevertheless mitigated by breast cancer-associated fibroblasts (bCAFs) in a manner that defines MCL-1 as another critical therapeutic target. bCAFs favor MCL-1 expression and apoptotic resistance in luminal cancer cells in a IL-6 dependent manner while their own, robust, survival also relies on MCL-1. ...[more]
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