Ontology highlight
ABSTRACT:
SUBMITTER: Zang G
PROVIDER: S-EPMC6756056 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Zang Guangxiang G Mu Yabing Y Gao Linlin L Bergh Anders A Landström Marene M
Oncogene 20190131 22
Prostate cancer disseminates primarily into the adjacent lymph nodes, which is related to a poor outcome. Atypical protein kinase C ζ (PKCζ) is highly expressed in aggressive prostate cancer and correlates with Gleason score, clinical stage, and poor prognosis. Here, we report the molecular mechanisms of PKCζ in lymphatic metastasis during prostate cancer progression. Using zinc-finger nuclease technology or PKCζ shRNA lentiviral particles, and orthotopic mouse xenografts, we show that PKCζ-knoc ...[more]