Ontology highlight
ABSTRACT:
SUBMITTER: Martin E
PROVIDER: S-EPMC6756107 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Martin Elodie E Amar Majid M Dalle Carine C Youssef Ihsen I Boucher Céline C Le Duigou Caroline C Brückner Matthias M Prigent Annick A Sazdovitch Véronique V Halle Annett A Kanellopoulos Jean M JM Fontaine Bertrand B Delatour Benoît B Delarasse Cécile C
Molecular psychiatry 20180622 1
Extracellular aggregates of amyloid β (Aβ) peptides, which are characteristic of Alzheimer's disease (AD), act as an essential trigger for glial cell activation and the release of ATP, leading to the stimulation of purinergic receptors, especially the P2X7 receptor (P2X7R). However, the involvement of P2X7R in the development of AD is still ill-defined regarding the dual properties of this receptor. Particularly, P2X7R activates the NLRP3 inflammasome leading to the release of the pro-inflammato ...[more]