Ontology highlight
ABSTRACT:
SUBMITTER: Raimondi F
PROVIDER: S-EPMC6756116 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Raimondi Francesco F Inoue Asuka A Kadji Francois M N FMN Shuai Ni N Gonzalez Juan-Carlos JC Singh Gurdeep G de la Vega Alicia Alonso AA Sotillo Rocio R Fischer Bernd B Aoki Junken J Gutkind J Silvio JS Russell Robert B RB Russell Robert B RB
Oncogene 20190723 38
Oncodriver genes are usually identified when mutations recur in multiple tumours. Different drivers often converge in the activation or repression of key cancer-relevant pathways. However, as many pathways contain multiple members of the same gene family, individual mutations might be overlooked, as each family member would necessarily have a lower mutation frequency and thus not identified as significant in any one-gene-at-a-time analysis. Here, we looked for mutated, functional sequence positi ...[more]