Ontology highlight
ABSTRACT:
SUBMITTER: Heuze ML
PROVIDER: S-EPMC6756789 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Heuzé Mélina L ML Sankara Narayana Gautham Hari Narayana GHN D'Alessandro Joseph J Cellerin Victor V Dang Tien T Williams David S DS Van Hest Jan Cm JC Marcq Philippe P Mège René-Marc RM Ladoux Benoit B
eLife 20190905
Adherens junction (AJ) assembly under force is essential for many biological processes like epithelial monolayer bending, collective cell migration, cell extrusion and wound healing. The acto-myosin cytoskeleton acts as a major force-generator during the de novo formation and remodeling of AJ. Here, we investigated the role of non-muscle myosin II isoforms (NMIIA and NMIIB) in epithelial junction assembly. NMIIA and NMIIB differentially regulate biogenesis of AJ through association with distinct ...[more]