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Metabolic remodeling induced by mitokines in heart failure.

ABSTRACT: The prevalence rates of heart failure (HF) are greater than 10% in individuals aged >75 years, indicating an intrinsic link between aging and HF. It has been recognized that mitochondrial dysfunction contributes to the pathology of HF. Mitokines are a type of cytokines, peptides, or signaling pathways produced or activated by the nucleus or the mitochondria through cell non-autonomous responses during cellular stress. In addition to promoting the communication between the mitochondria and the nucleus, mitokines also exert a systemic regulatory effect by circulating to distant tissues. It is noteworthy that increasing evidence has demonstrated that mitokines are capable of reducing the metabolic-related HF risk factors and are associated with HF severity. Consequently, mitokines might represent a potential therapy target for HF.

SUBMITTER: Duan J

PROVIDER: S-EPMC6756899 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Metabolic remodeling induced by mitokines in heart failure.

Duan Jiahao J Chen Zijun Z Wu Yeshun Y Zhu Bin B Yang Ling L Yang Chun C

Aging 20190909 17

The prevalence rates of heart failure (HF) are greater than 10% in individuals aged >75 years, indicating an intrinsic link between aging and HF. It has been recognized that mitochondrial dysfunction contributes to the pathology of HF. Mitokines are a type of cytokines, peptides, or signaling pathways produced or activated by the nucleus or the mitochondria through cell non-autonomous responses during cellular stress. In addition to promoting the communication between the mitochondria and the nu ...[more]

PMID: 31498116

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