Dataset Information

Association of BMI with Linear Growth and Pubertal Development.

ABSTRACT: OBJECTIVE:The aim of this study was to investigate the relationship of BMI with subsequent statural growth among children born in the era of the obesity epidemic. METHODS:Among 18,271 children from Belarus (n?=?16,781, born 1996 to 1997) and the United States (n?=?1,490, born 1999 to 2002), multivariable linear and ordinal logistic regression was used to analyze associations of BMI z score from infancy to adolescence with subsequent standardized length and height velocity, standing height and its components (trunk and leg lengths), and pubertal timing. RESULTS:The prevalence of early adolescent obesity was 6.2% in Belarus and 12.8% in the United States. In both Belarusian and US children, higher BMI z scores in infancy and childhood were associated with faster length and height velocity in early life, while higher BMI z scores during middle childhood were associated with slower length and height velocity during adolescence. Associations with greater standing height and trunk length and earlier pubertal development in adolescence were stronger for BMI z scores at middle childhood than BMI z scores at birth or infancy. CONCLUSIONS:These findings in both Belarus and the United States support the role of higher BMI in accelerating linear growth in early life (taller stature and longer trunk length) but earlier pubertal development and slower linear growth during adolescence.

SUBMITTER: Aris IM

PROVIDER: S-EPMC6756952 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Association of BMI with Linear Growth and Pubertal Development.

Aris Izzuddin M IM Rifas-Shiman Sheryl L SL Zhang Xun X Yang Seungmi S Switkowski Karen K Fleisch Abby F AF Hivert Marie-France MF Martin Richard M RM Kramer Michael S MS Oken Emily E

Obesity (Silver Spring, Md.) 20190903 10

<h4>Objective</h4>The aim of this study was to investigate the relationship of BMI with subsequent statural growth among children born in the era of the obesity epidemic.<h4>Methods</h4>Among 18,271 children from Belarus (n = 16,781, born 1996 to 1997) and the United States (n = 1,490, born 1999 to 2002), multivariable linear and ordinal logistic regression was used to analyze associations of BMI z score from infancy to adolescence with subsequent standardized length and height velocity, standin ...[more]

PMID: 31479205

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Project description:ImportanceWhether physical development and rapid growth during the first 2 years of life are associated with puberty onset in girls remains unclear.ObjectiveTo examine the associations of infant physical development and rapid growth with the timing of puberty onset in girls.Design, setting, and participantsThis prospective birth cohort study included girls whose mothers had participated in a randomized, double-blind cluster trial of micronutrient supplementation with a daily capsule of folic acid, iron and folic acid, or multiple micronutrients during pregnancy. A total of 547 singleton girls in rural western China who were born after 2004 were followed up at 3, 6, 12, and 24 months of age and were eligible for long-term follow-up. Of these, 294 adolescent girls (aged 10-12 years), representing 53.7% of the total sample, were included in the follow-up interview that was conducted from June 1 through December 31, 2016. Data analyses were conducted from November 1, 2019, to May 30, 2020.ExposuresInfant weight and length were assessed at birth and 3, 6, 12, and 24 months of age. Rapid growth, defined as a weight-for-age or length-for-age z score increase of greater than 0.67, was calculated during 5 periods: birth to 3 months, birth to 6 months, 6 to 12 months, 12 to 24 months, and birth to 24 months of age.Main outcomes and measuresPuberty stage was assessed using the standardized Tanner staging system. Onset of puberty was defined as attaining Tanner stage 2 of breast development or pubic hair growth, and the corresponding age at follow-up was recorded.ResultsOf 294 girls included in the analysis (mean [SD] age, 11.25 [0.57] years), the median age of puberty onset was 11 (interquartile range, 10-11) years. A significant association with puberty onset was found for infancy weight-for-age z score at 12 months of age (adjusted hazard ratio [HR], 1.20; 95% CI, 1.01-1.44) and rapid weight gain from birth to 24 months of age (adjusted HR, 1.40; 95% CI, 1.01-1.93) and birth to 3 months of age (adjusted HR, 1.39; 95% CI, 1.02-1.91). However, length-related indicators during early life were not associated with adolescent puberty onset.Conclusions and relevanceThis study found that a higher weight-for-age z score and rapid weight gain during infancy, particularly from birth to 3 months of age, were associated with an increased likelihood of puberty onset in girls. These findings suggest that weight-related indicators may serve as proxies of puberty onset among adolescent girls.

Dataset Information

Association of BMI with Linear Growth and Pubertal Development.

Publications

Association of BMI with Linear Growth and Pubertal Development.

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