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Seeing is believing: our evolving view of kinetochore structure, composition, and assembly.

ABSTRACT: This review highlights three recent trends in the field of kinetochore biology: the proliferation of structural data for kinetochore protein complexes (including CBF3, Dam1c, Mis12cMIND, and CENP-NLChl4/Iml3); the growing consensus that the kinetochore is a dynamic structure whose composition changes as the cell cycle progresses; and the mounting evidence of multiple pathways whereby the microtubule-binding elements of the outer kinetochore may be recruited by inner kinetochore proteins. Our focus is on the two best-studied systems in the field: human and budding yeast kinetochores. This review will demonstrate the remarkable similarity of these two systems, as well as their intriguing differences.

SUBMITTER: Hamilton G

PROVIDER: S-EPMC6756984 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Seeing is believing: our evolving view of kinetochore structure, composition, and assembly.

Hamilton Grace G Dimitrova Yoana Y Davis Trisha N TN

Current opinion in cell biology 20190509

This review highlights three recent trends in the field of kinetochore biology: the proliferation of structural data for kinetochore protein complexes (including CBF3, Dam1c, Mis12c<sup>MIND</sup>, and CENP-NL<sup>Chl4/Iml3</sup>); the growing consensus that the kinetochore is a dynamic structure whose composition changes as the cell cycle progresses; and the mounting evidence of multiple pathways whereby the microtubule-binding elements of the outer kinetochore may be recruited by inner kinetoc ...[more]

PMID: 31078123

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