Ontology highlight
ABSTRACT:
SUBMITTER: Tarabini RF
PROVIDER: S-EPMC6757107 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Tarabini Renata Fioravanti RF Timmers Luís Fernando Saraiva Macedo LFSM Sequeiros-Borja Carlos Eduardo CE Norberto de Souza Osmar O
Scientific reports 20190923 1
Flexibility is a feature intimately related to protein function, since conformational changes can be used to describe environmental changes, chemical modifications, protein-protein and protein-ligand interactions. In this study, we have investigated the influence of the quaternary structure of 2-trans-enoyl-ACP (CoA) reductase or InhA, from Mycobacterium tuberculosis, to its flexibility. We carried out classical molecular dynamics simulations using monomeric and tetrameric forms to elucidate the ...[more]