Investigation of association between LINC00673 rs11655237 C>T and Wilms tumor susceptibility.

ABSTRACT:

Background

Wilms tumor (WT) is the most common pediatric renal malignancy. Previous genome-wide association studies have identified that the LINC00673 rs11655237 C>T polymorphism is associated with the risk of several types of cancer. However, few studies have investigated the association between LINC00673 rs11655237 C>T and WT susceptibility.

Method

We genotyped LINC00673 rs11655237 C>T in 145 patients with WT and 531 cancer-free controls recruited from southern Chinese children. The strength of association was estimated by odds ratios (ORs) and 95% confidence intervals (CIs).

Results

Our study indicated that there was no significant association between LINC00673 rs11655237 C>T polymorphism and WT risk under all the tested genetic models (CT vs CC: adjusted OR = 0.94

SUBMITTER: Gao X 

PROVIDER: S-EPMC6757132 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature