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Localised grey matter atrophy in multiple sclerosis is network-based: a coordinate-based meta-analysis.


ABSTRACT: AIM:To test the network degeneration hypothesis in multiple sclerosis (MS) with a two-stage coordinate-based meta-analysis by: (1) characterising regional selectivity of grey matter (GM) atrophy and (2) testing for functional connectivity involving these regions. MATERIALS AND METHODS:Meta-analytic sources included 33 journal articles (1,666 MS patients and 1,269 healthy controls) with coordinate-based results from voxel-based morphometry analysis demonstrating GM atrophy. Mass univariate and multivariate coordinate-based meta-analyses were performed to identify a convergent pattern of GM atrophy and determine inter-regional co-activation (as a surrogate of functional connectivity), with anatomical likelihood estimation and functional meta-analytic connectivity modelling, respectively. RESULTS:Localised GM atrophy was demonstrated in the thalamus, putamen, caudate, sensorimotor cortex, insula, superior temporal gyrus, and cingulate gyrus. This convergent pattern of atrophy displayed significant inter-regional functional co-activations. CONCLUSION:In MS, GM atrophy was regionally selective, and these regions were functionally connected. The meta-analytic model-based results of this study are intended to guide future development of quantitative neuroimaging markers for diagnosis, evaluating disease progression, and monitoring treatment response.

SUBMITTER: Chiang FL 

PROVIDER: S-EPMC6757337 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Localised grey matter atrophy in multiple sclerosis is network-based: a coordinate-based meta-analysis.

Chiang F L FL   Wang Q Q   Yu F F FF   Romero R S RS   Huang S Y SY   Fox P M PM   Tantiwongkosi B B   Fox P T PT  

Clinical radiology 20190814 10


<h4>Aim</h4>To test the network degeneration hypothesis in multiple sclerosis (MS) with a two-stage coordinate-based meta-analysis by: (1) characterising regional selectivity of grey matter (GM) atrophy and (2) testing for functional connectivity involving these regions.<h4>Materials and methods</h4>Meta-analytic sources included 33 journal articles (1,666 MS patients and 1,269 healthy controls) with coordinate-based results from voxel-based morphometry analysis demonstrating GM atrophy. Mass un  ...[more]

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