Ontology highlight
ABSTRACT:
SUBMITTER: Perin-Dureau F
PROVIDER: S-EPMC6757916 | biostudies-literature | 2002 Jul
REPOSITORIES: biostudies-literature
Perin-Dureau Florent F Rachline Julie J Neyton Jacques J Paoletti Pierre P
The Journal of neuroscience : the official journal of the Society for Neuroscience 20020701 14
Ifenprodil is a noncompetitive antagonist of NMDA receptors highly selective for the NMDA receptor 2B (NR2B) subunit. It is widely used as a pharmacological tool to discriminate subpopulations of NMDA receptors, and derivatives are currently being developed as candidate neuroprotectants. Despite numerous studies on the mechanism of action of ifenprodil on NMDA receptors, the structural determinants responsible for the subunit selectivity have not been identified. By combining functional studies ...[more]