Ontology highlight
ABSTRACT:
SUBMITTER: Eto K
PROVIDER: S-EPMC6758394 | biostudies-literature | 2002 May
REPOSITORIES: biostudies-literature
Eto Ko K Ogasawara Miki M Umemura Ken K Nagai Yasuo Y Kimura Hideo H
The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501 9
Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain. Physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and alter the induction of hippocampal long-term potentiation (LTP). Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, ...[more]