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Hydrogen sulfide is produced in response to neuronal excitation.


ABSTRACT: Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain. Physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and alter the induction of hippocampal long-term potentiation (LTP). Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate, as well as by electrical stimulation. This increased CBS activity is regulated by a pathway involving Ca2+/calmodulin. In addition, LTP is altered in CBS knock-out mice. These observations suggest that H2S is produced by CBS in response to neuronal excitation and that it may regulate some aspects of synaptic activity.

SUBMITTER: Eto K 

PROVIDER: S-EPMC6758394 | biostudies-literature | 2002 May

REPOSITORIES: biostudies-literature

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Hydrogen sulfide is produced in response to neuronal excitation.

Eto Ko K   Ogasawara Miki M   Umemura Ken K   Nagai Yasuo Y   Kimura Hideo H  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501 9


Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain. Physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and alter the induction of hippocampal long-term potentiation (LTP). Here we use cystathionine beta-synthase (CBS) knock-out mice to clearly show that CBS produces endogenous H2S in the brain and that H2S production is greatly enhanced by the excitatory neurotransmitter l-glutamate,  ...[more]

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