Ontology highlight
ABSTRACT:
SUBMITTER: Kakani P
PROVIDER: S-EPMC6758949 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Kakani Parik P Kajla Mithilesh M Choudhury Tania Pal TP Gupta Lalita L Kumar Sanjeev S
Journal of innate immunity 20190329 6
We characterized the dual oxidase (Duox) gene in the major Indian malaria vector Anopheles stephensi, which regulates the generation of reactive oxygen species. The AsDuox gene encodes for a 1,475-amino-acid transmembrane protein that contains an N-terminal noncytoplasmic heme peroxidase domain, a calcium-binding domain, seven transmembrane domains, and a C-terminal cytoplasmic NADPH domain. Phylogenetic analyses revealed that A. stephensi Duox protein is highly conserved and shares 97-100% amin ...[more]